Two-stage optimization process for formulation of chitosan microspheres

Formulation, optimization, and pharmacodynamic evaluation of chitosan/phospholipid/β-cyclodextrin microspheres

Cholinergic neurotransmission loss is the main cause of cognitive impairment in patients with Alzheimer's disease. Phospholipids (PLs) play an essential role in memory and learning abilities. Moreover, PLs act as a source of choline in acetylcholine synthesis. This study aimed to prepare and optimize the formulation of chitosan/phospholipid/β-cyclodextrin (CTS/PL/β-CD) microspheres that can imp...

Formulation Development and Evaluation of Aceclofenac Chitosan Microspheres

INTRODUCTION Oral controlled release dosage forms have been developed over the past three decades due to their considerable therapeutic advantages such as ease of administration, patient compliance and flexibility in formulation. The controlled release drug delivery systems are aimed at controlling the rate of drug delivery, sustaining the duration of therapeutic activity and/or targeting the d...

Residuals based process capability indices for two-stage processes

The manufacturing operations often involve multistage processes where the process capability of each stage is affected by the process capability of its precedent processes. This property is known as the cascade property. The purpose of this paper is to estimate the process capability of the second stage of two-stage process while the cascade property impact is removed using residuals analysis. ...

formulation and characterization of ionotropic cross-linked chitosan microspheres for controlled release of ascorbic acid

Formulation and evaluation of Zidovudine loaded chitosan Microspheres for controlled release

The aim of this study was to formulate and evaluate zidovudine loaded chitosan microspheres for controlled drug release. Microspheres were prepared by emulsification method using gluteraldehyde as crosslinking agent. The prepared microspheres were characterized for their yield and drug loading, as well by Fourier transform infrared spectroscopy (FTIR), X-ray powder diffractometry and Scanning e...